منابع مشابه
Fit for the Eye: Aptamers in Ocular Disorders
For any new class of therapeutics, there are certain types of indications that represent a natural fit. For nucleic acid ligands in general, and aptamers in particular, the eye has historically been an attractive site for therapeutic intervention. In this review, we recount the discovery and early development of three aptamers designated for use in ophthalmology, one approved (Macugen), and two...
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Duplexed aptamers (DAs) are engineered by hybridizing an aptamer-complementary element (ACE, e.g. a DNA oligonucleotide) to an aptamer; to date, ACEs have been presumed to sequester the aptamer into a non-binding duplex state, in line with a conformational selection-based model of ligand binding. Here, we uncover that DAs can actively bind a ligand from the duplex state through an ACE-regulated...
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A broad review of recent research work on the preparation and the remarkable properties of intercalation compounds of graphite, covering a wide range of topics from the basic chemistry, physics and materials science to engineering applications.
متن کاملPerspective: Aptamers as Drugs
Aptamers are nucleic acid molecules, either single-stranded RNA or DNA, that form secondary structures capable of eliciting affinities to a variety of targets ranging from small organics to whole proteins. They can be quickly developed and are relatively inexpensive to manufacture. Aptamers have the potential to be used as novel drug products, but lacks general acceptance within the pharmaceuti...
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I N B R I E F We are used to thinking of intelligence as largely a matter of genetic inheritance, but that is not the whole picture. What we do aff ects our mental wellbeing: staying physically and mentally active helps us stay sharp as we age. Nevertheless, our personal eff orts to bolster cognitive enhancement cannot forestall all declines in our cognitive performance. What is especially surp...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2019
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.9b06450